Molecular Mechanism of α2β1 Integrin Interaction with Human Echovirus 1

Thank you for submitting your manuscript for consideration by the EMBO Journal. First of all, please let me apologise for the length of time taken to get back to you with a decision this was due firstly to some difficulty in finding three appropriate referees, and secondly to a delay in receiving the final report. However, your manuscript has now been seen by three referees whose comments are enclosed. As you will see, referees 1 and 3 express interest in your study and are broadly positive, although do highlight a number of concerns that would need to be addressed before we could consider publication. On the other hand, referee 2 (whose opinion is stated more explicitly in his/her confidential comments to the editor) finds that it does not make a significant conceptual advance beyond previous work (from your lab and others) that already suggested that EV1 binds to the inactive conformation of the integrin receptor.